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He, Chuan
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overview Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
One or more keywords matched the following items that are connected to He, Chuan
Item TypeName
Concept Breast Neoplasms
Concept Gastrointestinal Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Liver Neoplasms
Concept Ovarian Neoplasms
Concept Mixed Function Oxygenases
Concept RNA, Neoplasm
Concept Biomarkers, Tumor
Concept Tumor Necrosis Factor-alpha
Concept Drug Resistance, Neoplasm
Concept Genes, Tumor Suppressor
Concept Neoplasms, Second Primary
Concept Endometrial Neoplasms
Concept Neoplasm Metastasis
Concept Neoplasm Recurrence, Local
Concept Gene Expression Regulation, Developmental
Concept Multidrug Resistance-Associated Proteins
Concept Genetic Association Studies
Concept Embryonic Development
Concept S-Phase Kinase-Associated Proteins
Concept Tumor Burden
Concept Growth and Development
Concept Microphthalmia-Associated Transcription Factor
Concept Skin Neoplasms
Concept Genome-Wide Association Study
Concept Endoplasmic Reticulum-Associated Degradation
Concept Tumor Microenvironment
Concept Cell Line, Tumor
Concept Brain Neoplasms
Concept Neoplasm Proteins
Concept Neoplasms
Academic Article Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.
Academic Article Expression of multidrug resistance efflux pump gene norA is iron responsive in Staphylococcus aureus.
Academic Article Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Academic Article Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA.
Academic Article HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis.
Academic Article TET1 plays an essential oncogenic role in MLL-rearranged leukemia.
Academic Article Blood-brain barrier permeable gold nanoparticles: an efficient delivery platform for enhanced malignant glioma therapy and imaging.
Academic Article Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming.
Academic Article Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.
Academic Article Preparation and characterization of the native iron(II)-containing DNA repair AlkB protein directly from Escherichia coli.
Academic Article An exceptionally selective lead(II)-regulatory protein from Ralstonia metallidurans: development of a fluorescent lead(II) probe.
Academic Article Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Academic Article Direct functionalization of arenes by primary alcohol sulfonate esters catalyzed by gold(III).
Academic Article Potential functional roles of DNA demethylation intermediates.
Academic Article N6-methyldeoxyadenosine marks active transcription start sites in Chlamydomonas.
Academic Article TET family proteins: oxidation activity, interacting molecules, and functions in diseases.
Academic Article Probing the structure and function of the Escherichia coli DNA alkylation repair AlkB protein through chemical cross-linking.
Academic Article Direct repair of the exocyclic DNA adduct 1,N6-ethenoadenine by the DNA repair AlkB proteins.
Academic Article A non-heme iron-mediated chemical demethylation in DNA and RNA.
Academic Article Oxidative dealkylation DNA repair mediated by the mononuclear non-heme iron AlkB proteins.
Academic Article Cancer: Damage prevention targeted.
Academic Article Efficient functionalization of aromatic C-H bonds catalyzed by gold(III) under mild and solvent-free conditions.
Academic Article Interaction of human and bacterial AlkB proteins with DNA as probed through chemical cross-linking studies.
Academic Article Synthesis of a FTO inhibitor with anticonvulsant activity.
Academic Article RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.
Academic Article Detecting hepatocellular carcinoma in blood.
Academic Article The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Academic Article Identification of MLL-fusion/MYC?miR-26?TET1 signaling circuit in MLL-rearranged leukemia.
Academic Article A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Academic Article m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition.
Academic Article DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?
Academic Article Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning.
Academic Article RNA modifications modulate gene expression during development.
Academic Article FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
Academic Article RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article Phasing Gene Expression: mRNA N6-Methyladenosine Regulates Temporal Progression of Mammalian Cortical Neurogenesis.
Academic Article Epitranscriptomic influences on development and disease.
Academic Article "Gamete On" for m6A: YTHDF2 Exerts Essential Functions in Female Fertility.
Grant Mechanisms of Pancreatic Cancer Inhibition by SPARC
Grant Mechanism of SPARC peptide FSEC inhibition of angiogenesis in neuroblastoma
Academic Article Inhibition of Copper Transport Induces Apoptosis in Triple-Negative Breast Cancer Cells and Suppresses Tumor Angiogenesis.
Academic Article Regulation of Gene Expression by N6-methyladenosine in Cancer.
Academic Article METTL14 is essential for ß-cell survival and insulin secretion.
Academic Article Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Academic Article 5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype.
Academic Article m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Academic Article Detailed modeling of positive selection improves detection of cancer driver genes.
Academic Article 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.
Academic Article YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators.
Academic Article Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.
Academic Article Genetic analyses support the contribution of mRNA N6-methyladenosine (m6A) modification to human disease heritability.
Academic Article Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.
Academic Article Functional analysis of a SOX10 gene mutation associated with Waardenburg syndrome II.
Academic Article Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.
Academic Article Identification and functional analysis of a novel mutation in the SOX10 gene associated with Waardenburg syndrome type IV.
Academic Article METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Academic Article HRD1-mediated METTL14 degradation regulates m6A mRNA modification to suppress ER proteotoxic liver disease.
Academic Article Utility of Perioperative Measurement of Cell-Free DNA and Circulating Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review.
Academic Article FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development.
Academic Article Development of Mild Chemical Catalysis Conditions for m1A-to-m6A Rearrangement on RNA.
Academic Article Genome-wide profiling of 5-hydroxymethylcytosines in circulating cell-free DNA reveals population-specific pathways in the development of multiple myeloma.
Academic Article N6-adenomethylation of GsdmC is essential for Lgr5+ stem cell survival to maintain normal colonic epithelial morphogenesis.
Academic Article The mechanism underlying redundant functions of the YTHDF proteins.
Concept Pancreatitis-Associated Proteins
Concept Circulating Tumor DNA
Concept Triple Negative Breast Neoplasms
Grant Discovering the epigenetics of RNA modifications
Grant RNA methylation and regulatory T cells
Grant Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Grant Recognition and mechanism of N6-methyl adenosine modifications
Grant Global Cysteine Modifications in Human Pathogens
Grant Direct Oxidative Nucleic Acids Demethylation
Grant Base-resolution sequencing of m6A in RNA
Grant Direct Oxidative Nucleic Acids Demethylation
Academic Article Advances in targeting RNA modifications for anticancer therapy.
Academic Article YTHDF2/m6 A/NF-?B axis controls anti-tumor immunity by regulating intratumoral Tregs.
Academic Article YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.
Academic Article PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Academic Article PETCH-DB: a Portal for Exploring Tissue-specific and Complex disease-associated 5-Hydroxymethylcytosines.
Academic Article Adrenergic and mesenchymal signatures are identifiable in cell-free DNA and correlate with metastatic disease burden in children with neuroblastoma.
Academic Article RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.
Academic Article 5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer.
Academic Article m6A RNA methylation regulates mitochondrial function.
Search Criteria
  • Development
  • Function
  • Tumor
  • associated
  • Regulatory T Cells